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However, excessive activation of ATF4 in PD models is pathologically associated with progressive loss of dopaminergic neurons in the substantia nigra

Despite the thermodynamically highly favorable reverse reaction, PfGrx C88S (S 2 ) reacted very slowly with roGFP2 WT (SH) 2 most likely due to the instability and high energy of the Grx(SSR) intermediate

doi: 10.1172/JCI118990 512 Cabral-MarquesOMarquesAGiilLMDe VitoRRademacherJGntherJet al
