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However, their clinical use is restricted by safety concerns and suboptimal pharmacokinetics

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Thus, these compounds serve two functions: facilitating intra-mitochondrial transfer of long-chain fatty acids and detoxifying mitochondria by transferring acyl-carnitines back into the cytosol, where they become toxic 16,33

On a pu observer en effet que l'effet de synergie avec la L-carnitine s'exerce galement avec une combinaison directe sous forme de sel et notamment de chlorhydrate de L-carnitinate de L-lysine.We have observed that the synergistic effect with L-carnitine is also exerted with a direct combination in the form of salt and in particular of hydrochloride of L-carnitinate of L-lysine