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If a drug is taken into the gastrointestinal tract (GI tract), where it enters the hepatic portal system through the portal vein, it becomes well-metabolized and is said to show the first pass effect
Nat Rev Mol Cell Biol 24:273287 Dimitrova LN, Kuroha K, Tatematsu T, Inada T (2009) Nascent peptide-dependent translation arrest leads to Not4p-mediated protein degradation by the proteasome
