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251 In tumor-bearing mice, EPA antagonizes the loss of skeletal muscle proteins in cancer cachexia by suppressing ATP-dependent proteolysis and the expression of 20S proteasome alpha-subunits and the p42 regulator, 252 which can also prevent NF-B nuclear accumulation, thereby dampening proteolysis-inducing factor-triggered ubiquitinproteasome proteolysis

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49 Therefore, the role of neutrophils in defending against inflammation and pathogens is greatly weakened during aging (Fig