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In adult patients with T2DM, intramuscular injections (eight to 10 loading injections of 1,000 g each over one to two weeks, followed by monthly 1,000-g injections) or oral vitamin B12 1,000 to 2,000 g daily are sufficient to correct vitamin B12 deficiency.9 Patients should be monitored for response to therapy

At the same time, its cytoplasmic domain connects to the actin cytoskeleton and functions to organize it, affecting the formation of the stress fibers and focal adhesion complexes, which are essential for cell migration and the development of fibrosis [52,53]

(November 2004)

5 (2018): e0197187, 10.1371/JOURNAL.PONE.0197187