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30-50% oral)
Differently, Kempf and coworkers investigated the effect of two different doses of coffee (4 and 8 cups, corresponding to 600 and 1200 mL respectively) by using a simple experimental design: subjects had to follow 4 weeks of restrictive diet, followed by 4 weeks with 4 cups coffee/day and 4 weeks of 8 cups coffee/day [43]
Vitamin B12 is essential to the human body
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