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Consequently, targeted therapies aimed at hypoxic signaling pathways necessitate precise control of drug dosages and timing to mitigate side effects and the development of resistance

This work has been funded by the German Research Foundation (DFG) through grant LE LE2905/1-2 to LIL as part of the priority program 1710 Dynamics of Thiol-based Redox Switches in Cellular Physiology

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doi: 10.1210/en.2015-1546