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While the arsenic exposure was the root cause of his symptoms, it is unclear how his multiple PED use exacerbated or hastened his ultimately fatal condition
The alternative efflux substrate of ASCT2, Serine can derive from glucose via a three enzymes pathway, i.e., phosphoglycerate dehydrogenase, phosphoserine aminotransferase, and phosphoserine phosphatase (resumed by the dotted arrow of Figure 1B)
Studies indicate that p53 binds the SLC7A11 promoter, suppressing its expression and limiting GSH production, thereby promoting ferroptosis (83,84)
doi: 10.1016/j.neulet.2006.08.033
