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Description
The primary role of this enzyme is to facilitate the fourth step in pyrimidine synthesis by converting dihydroorotate (DHO) into orotate ( Figure 1 )
[DOI] [PMC free article] [PubMed] [Google Scholar] 398.Capdevila J, Wirth LJ, Ernst T, Ponce Aix S, Lin CC, et al
The elevated levels of Glu in the diabetic vitreoretinal are thought to be mediated by the dysfunction of glutamate transporters on retinal Mller cells and possibly, due to the decreased expression of glutamine synthase (Li and Puro, 2002
Dual-target compounds for Alzheimers disease: Natural and synthetic AChE and BACE-1 dual-inhibitors and their structure-activity relationship (SAR)
