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GCLC succinylation leads to a decreased enzymatic activity To precisely locate the K sites undergoing succinylation modification, we individually mutated all forty lysine sites of GCLC to arginine (R) (mimicking the desuccinylated state)

For example, the term about, when referring to a value can be meant to encompass variations of, in some embodiments, 100% in some embodiments 50%, in some embodiments 20%, in some embodiments 10%, in some embodiments 5%, in some embodiments 1%, in some embodiments 0.5%, and in some embodiments 0.1% from the specified amount, as such variations are appropriate to perform the disclosed methods or employ the disclosed compositions

Dado que este grupo consta de tres pptidos, se denomina " tripptido "

Although concurrent short-term KD did not rescue cMPC1 / hearts from rapid decompensation and early mortality after pressure overload, 3 weeks of the KD before transverse aortic constriction is sufficient to rescue this phenotype