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Are tumor cells necessarily more sensitive to ferroptosis
Both mitochondria and the ER maintain separate pools of GSH, independently regulated apart from the cytosolic GSH pool
Indeed, recent studies have shown that HIF-2 can be targeted by selective inhibitors and have indicated that these molecules effectively suppress cancer cell growth and tumor angiogenesis characteristics in ccRCC 79,80,81,82
Uric acid and its oxidized derivatives may exhibit prooxidant activities
