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Since the concentration of the phospholipid component of surfactant is estimated to be 5 mg/ml, surfactant may not always have a protective function, but may inactivate the innate CRP-mediated defense allowing PC-expressing bacteria to adhere to and invade alveolar epithelial cells (214)

Some of these, such as c-jun and c-fos, are known to be redox sensitive and can be inactivated by oxidation at critical Cys residues necessary for their DNA-binding activity (1)

[DOI] [PubMed] [Google Scholar] 77.Zhang A., Sun H., Wang X

The increase in phosphatidylcholine synthesis is the result of inosine activation of PKA activity