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The C-terminal portion of the peptide ligand first engages the ECD through an alpha-helical interaction, forming an initial complex that positions the ligand for subsequent insertion of its N-terminal residues into the transmembrane domain (TMD)
Vitamin B12 consists of four basic chemical forms of cobalamin: methylcobalamin (MeCbl), adenosylcobalamin (AdCbl), hydroxocobalamin (OHCbl), and cyanocobalamin (CNCbl)
