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If the HSAT is negative, and sleep apnea is still suspected, a polysomnography is recommended to ensure accuracy of the results

The CF mucus contains less water than normal mucus and presents mucin fibers (7080%), DNA, actin and other macromolecules, which form a cross-linked network where the mesh size is reduced from above 500 nm (in healthy patients) to 300100 nm in CF patients, depending on their conditions and on the disease stage (Ensign et al., 2014

Eduardo Martin-Sanz, Hospital de Getafe, Spain Updates Copyright 2018 Canceri, Brown, Watson and Browne