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However, Sp-L-DOPA combination showed consistent negative geotaxis even during the wearing-off phase, representing substantial alleviation of L-DOPA toxicity and promotion of enhanced mitochondrial and cellular health in dopaminergic neurons

The mechanism could be that DAPA binding to FPN led to the inhibition of ubiquitination degradation of FPN[163], which provided a new perspective for DAPA application in the treatment of DKD

Finally, a four-year, multicenter, clinical trial in 421 diabetic patients with distal symmetric sensorimotor polyneuropathy found no difference between oral administration of 600 mg/day of lipoic and placebo on the primary endpoint, a composite score that assessed neuropathic impairment of the lower limbs and nerve conduction (78)