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Description
Besides stimulating POMC transcription and ACTH biogenesis, CRH stimulates the release of ACTH from corticortophs via CRH-R1 leading to a biphasic response with the fast release of a pre-synthesized pool of ACTH, and the slower and sustained release of newly-synthesized ACTH (57)

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Second, a substantial portion of evidence comes from animal models, which may not fully reflect human physiological responses [17]

LinMGongJWuLLinXZhangYLinWet al
