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The key findings from this clinical program include significant reductions in body weight and fat mass in treatment groups compared to placebo, preferential loss of abdominal and visceral adipose tissue, no changes in serum IGF-1 levels at any dose tested, no negative effects on glucose metabolism or insulin sensitivity, no significant adverse events related to metabolic or endocrine disruption, and safety profile indistinguishable from placebo for most parameters

This dual mechanism approach allows researchers to examine whether combined pathway activation produces different metabolic effects compared to single-pathway targeting

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The topic becomes much more relevant when symptoms last longer than expected, feel stronger over time, or appear alongside a more complicated medical picture