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Given the strong female predominance of AITD and the midlife rise in metabolic risk during the menopausal transition, targeted trials in perimenopausal and postmenopausal women are warranted, with attention to hormone status, body-composition change, cardiovascular risk, and dose adjustments of thyroid medications during weight loss [1,2,66] (Figure 2)

Like other enzymes that transfer two-carbon groups, transketolase requires thiamine pyrophosphate (TPP) as a co-factor in the transfer reaction

10.1371/journal.pgen.1004841 [DOI] [PMC free article] [PubMed] [Google Scholar] Zhang H., Xu W., Li B., Zhang K., Wu Y., Xu H., et al