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10.1002/14651858.cd000229.pub2 115

The ability to incorporate systemic modifiers such as diabetes, obesity, or aging into these models further enhances their relevance, allowing researchers to explore how systemic inflammation, metabolic dysregulation, or immunosenescence influences disease susceptibility and the capacity for repair [71, 72, 73, 74, 75]

The recombinant protein retained Lys-PG hydrolase activity (Supplementary Fig

Table 2 Disease-associated astrocytes (DAAs) and reactive astrocytes
