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Applying tretinoin to even slightly damp skin can increase penetration and lead to a catastrophic level of irritation

This time scale would appear to make postsynaptic enzyme-dependent mechanisms less likely candidates to provide the presynaptic coincidence signal during induction of t-LTD

Vasconcelos TBC, Josino ARNR, Macena JB, et al

COMT o-methylates catechol oestrogen metabolites and mediates their detoxification, and it is plausible that the activity of this enzyme is inhibited by the accumulation of the cysteine precursor homocysteine