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Further research is needed to elucidate the mechanisms by which NNMT operates in MetS and to develop therapeutic strategies targeting NNMT

(Picard et al., 2004) observed that overweight and obese patients could activate Sirtuin 1 (SIRT1) and Peroxisome proliferator-activated receptors (PPAR) through NAD + supplementation, resulting in weakened adipogenesis