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Indeed, the PDH complex, which decarboxylates glycolytically derived pyruvate to acetyl coenzyme A and links cytoplasmic glycolysis to the mitochondrial tricarboxylic acid (TCA) cycle, is modulated by reversible phosphorylation by PDH kinase (PDK)
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However, because of their low plasma and brain concentrations, it is unlikely that they contribute significantly to the anticonvulsant effects of VPA [10]
