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By increasing NO availability, arginine infusion may improve endothelial function and blood flow, potentially reducing vascular resistance and lowering blood pressure under certain conditions

Pain that eases after a bowel movement is often seen with IBS, while pain with fever or bleeding needs a workup

Doses greatly exceeding the nutritional requirements (for example, hundreds of milligrams daily) have not been studied in randomized trials for safety, so one should avoid mega doses in pregnancy unless treating a specific condition (such as pyridoxine-responsive seizures) under careful supervision

B12 absorption requires a protein called intrinsic factor , produced in the stomach