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IL-8 promotes the development of fibrosis through elastase-mediated activation of TGF- (Betensley et al., 2016

The results showed that DEX increased CD82 expression at both mRNA and protein levels as compared to sham group (Fig

Additionally, while targeting TGF- and its downstream effectors presents a promising therapeutic strategy for fibrosis, the challenge lies in achieving specificity and minimizing impacts on normal cellular functions

It displays broad antimicrobial abilities through various mechanisms including the sequestration of iron required for bacterial growth and direct membrane permeation ability, which are similar to the other AMPs mentioned earlier such as A and LL-37 (Cao et al., 2023)