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2021;16(8):e0255482
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Activation of the p53 pathway leads to renal tubular cell apoptosis and dysfunction, impacting both developmental nephrotoxicity by disrupting nephrogenesis during organogenesis and worsening existing adult kidney diseases
906 This is true for both the paradigm sarco(endo)plasmic reticulum calcium ATPase (SERCA) pumps and related transporters from the P 2A subclass that function in the ER and cis -Golgi in vertebrates, as well as the heavy metal transporting P 1B -type transporters described below ( vide infra ) (Figure 54)
