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In addition, peripheral BDNF levels, the most commonly used biomarker, cannot be relied on to accurately represent CNS activity due to systemic factors (e.g., inflammation, metabolic alterations, and platelet activation), thus stressing the need for direct neurotrophic biomarkers [321]

Doch mit zunehmendem Alter, bei Stress oder intensiver krperlicher Belastung kann die krpereigene Produktion an ihre Grenzen stoen

Another strategy is target-modification