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Apart from mutations, other significant factors accounting for -synuclein fibrillation are changes in pH of the microenvironment (Frey et al., 2024), presence of other metal ions temperature (Puspita et al., 2017), phosphorylation (Ghanem et al., 2022
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An abnormal type I IFN-associated pathway plays a critical role in the fibrosis, disease severity and progression of SSc
