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In support of this idea, when holoTC concentrations were subtracted from total vitamin B-12 concentrations, the remaining vitamin B-12, represented by the holohaptocorrin (holoHC) fraction of serum vitamin B-12, was unaffected by the concentration of plasma folate (Figure 8B)

Less commonly, patients develop pretibial dermopathy and acropachy, reflecting fibroblast activation in the skin and extremities [21]

This is an example of a positive feedback loop

[DOI] [PMC free article] [PubMed] [Google Scholar] 7.Sikiric P., Hahm K.B., Blagaic A.B., Tvrdeic A., Pavlov K.H., Petrovic A., Kokot A., Gojkovic S., Krezic I., Drmic D., et al