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1,2 These activities are constantly challenged by intrinsic and extrinsic perturbations, including increased protein synthesis, ER-Ca 2+ depletion, dysregulated redox homeostasis, energy deprivation, hypoglycemia, hypoxia, and inflammatory stimuli, resulting in improper protein conformation and misfolding, often referred to as nonnative or aberrant conformation
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[PMC free article: PMC5830076] [PubMed: 29225078] 111
Yu Y, Jin Y, Zhou J, et al
