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A previous study used a multimodal approach, combining peripheral neuromuscular electrophysiological assessment and TMS-electroencephalography technology (74), and found that, following fatigue induction, the oscillation energy of the g frequency band (30-45 Hz) of the motor cortex in the MS group decreases markedly, while the functional connectivity within and between the default and the frontoparietal control networks is weakened, which is negatively associated with the severity of fatigue (43,74,111)

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