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Description
With the metabolic reprogramming of NADPH, cancer cells increase the demand of NADPH for antioxidative effects and anabolic reactions
Mitochondrial generation of free radicals and hypoxic signaling
d , An in vitro kinase assay showed that PDK1 phosphorylated p70S6K but not Smurf1, as determined by a phosphoserine/threonine (p-S/T) antibody
IDH1 inhibitors were developed as part of the process of targeting mutant IDH1, with the Food and Drug Administration-approved mutant IDH1 inhibitor ivosidenib having activity also against the wild-type enzyme
