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In spite of those appealing features of MnO 2 nanostructures, some currently developed MnO 2 nanostructures are still lack of well-defined morphology, such as irregular nanosheets or uneven nanoparticles, which are not desirable for optimizing drug loading and controlling drug release

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Due to their short diffusion lengths and rapid scavenging, these radicals exert their effects within nanometer-to-submicrometer microdomains, making receptor-proximal membranes and specific enzyme complexes privileged initial targets [101103] (Fig

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