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The cell death induced by the B2M-ADC does not seem to be led by apoptosis but rather by necrosis 49

And as long as that continues, reimbursement becomes unworkable in multiple markets. That pricing pressure is reflected in global comparisons

Ophthalmological, psychometric and therapeutic investigation in two sisters with hereditary glutathione synthetase deficiency (5-oxoprolinuria)

Br J Pharmacol 118: 941950
