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Numerous viral coat proteins target RNAi-modified virus-resistant plants, including tobacco resistant to the beet necrotic yellow vein virus (BNYVV) [28], PVY-resistant potatoes [131], Nicotiana benthamiana resistant to the cucumber green mottle mosaic virus) [98], Prunus domestica and Nicotiana benthamiana resistant to the PPV [81], and Cucumis melo L

The only negative side effects the inoculated group reported were temporary injection site irritation and some mild fatigue

Considering that the copper-associated mitochondrial toxicity may have been delayed, we further explored the changes in the expression of skin irritation-related biomarkers at the genomic level

In a joint regression model including a snp:drug type interaction term, we determined the difference to be weakly significant ( P = 0.02)