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Description
Over-loss and muscle pooled SURMOUNT, BMI below 22 reached by about 7% (as early as week 12), toward about 15% by week 88 in the longest trial, clinical underweight under 0.4% (Almandoz 2026)

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Pollard, J.D., et al

A minority of patients experience a prolonged course lasting several months, particularly after long-term use at 20 mg
