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Interestingly, both in vivo and in vitro studies have shown that the accumulation of -syn in the mitochondria of human DA neurons leads to decreased complex I activity, increased production of ROS, reduced substrate-specific respiration, and increased mitophagy [86, 87]
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Neuroprotection in traumatic brain injury

doi: 10.1055/a-2307-8183 47 DamascenoR