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44 The corticotropin (ACTH) stimulation test is used to diagnose a variety of adrenopathic conditions, including endogenous or iatrogenic hyperadrenocorticism, as well as spontaneous hypoadrenocorticism.42, 45, 46 As a screening test for the diagnosis of naturally occurring hyperadrenocorticism, the ACTH response test has a diagnostic sensitivity of approximately 80% to 85% and a higher specificity than the LDDS test.45, 46 In a study by Kaplan and Peterson, only 15% of dogs with nonadrenal disease exhibited exaggerated response to ACTH stimulation

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pDC differentiation Bone-marrow-derived pDCs were differentiated as described by Mutagenetix ( Briefly, bone marrow cells from wild-type or Rab27a ash/ash mice were plated at 3 10 6 5 10 6 cells per ml in the presence of hFLT3L at 100 ng ml 1

Monitor for any unusual symptoms