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(2) Branched-Chain Amino Acids (BCAAs): Amino acids make up protein, and essential amino acids are not made naturally

Targeted studies in diabetic patients have shown that (1) chronic and severe pain significantly interferes with overall diabetes self-management (p=0.002 and p=0.0003, respectively), and (2) neuropathic pain significantly interferes with the quality of sleep measured by the Medical Outcomes Study Sleep Scale (MOS-Sleep Scale), the results of which were significantly worse in a sample of 255 PDPN patients than in the general population (n=1011), a chronic disease sample (n=3445), and postherpetic neuralgia patients (n=89) 170;171