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RAS-RAF-MEK-ERK MAP Kinases Pathway Stimulation of C-KIT or other receptor tyrosine kinase on the cellular membrane by extracellular growth factors provokes downstream activation of RAS and RAF kinases followed by phosphorylation of MEK and ERK, leading to activation of the MAPK pathway implicated in the regulation of cell proliferation, differentiation, and survival (90)

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In a healthy body, the heart and skeletal muscles rely heavily on the breakdown of fats for their energy needs