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Importantly, anti-PCSK9 therapy will decrease circulating LDL cholesterol while increasing the exposure of PCSK9- and LDLR-expressing tissues to LDL cholesterol, perhaps providing a partial explanation for the contradictory anti- and pro- cancer effects of PCSK9 inhibition seen in different tumor models

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Afshin-Majd S, Bashiri K, Kiasalari Z, Baluchnejadmojarad T, Sedaghat R, Roghani M (2017) Acetyl-l-carnitine protects dopaminergic nigrostriatal pathway in 6-hydroxydopamine-induced model of Parkinsons disease in the rat