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ClinicalTrials.gov

Energy metabolism and cortical spreading depression susceptibility Cortical spreading depression (CSD) is a neurophysiological phenomenon characterized by the strong depolarization of regional neurons or glial cells, spreading along the cortex to neighboring regions at a rate of 35 mm/min, ultimately leading to inhibition of neural activity (9)

The involvement of OCTN1 in cancer metabolism, is probably unrelated to the poor ability of this transporter to mediate carnitine transport, however, it is interesting to know that OCTN1 is involved in the uptake of anti-cancer drugs (Table 1) such as Cytarabine (Zheng et al., 2016), mitoxantrone and doxorubicin (Okabe et al., 2008)

It could mean the difference between successfully completing a gentle, five-minute movement session and triggering a debilitating, multi-day PEM crash that leaves them bedbound