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Dehydroascorbate reductase (DHAR) is a key enzyme involved in the recycling of ascorbate, which catalyses the glutathione (GSH)-dependent reduction of oxidized ascorbate (dehydroascorbate, DHA)

For instance, vitamin B2 (riboflavin) and the essential trace mineral selenium are necessary for the recycling [the enzyme glutathione reductase is considered a flavoenzyme (i.e., it needs a coenzyme form of riboflavin, flavin adenine dinucleotide to operate)] of and use [the enzyme glutathione peroxidase is a selenoprotein (i.e., it needs its cofactor selenium to operate)] of glutathione, respectively

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