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Sema4D promotes dendritic branching in hippocampal neurons via the PlexinB1 receptor, PI3 Kinase and mTor pathways (Vodrazka et al., 2009)

Early genetically engineered NF1 heterozygous mouse models failed to recapitulate the characteristic symptoms of NF1 [50]

Similarly, another long-acting analogue of somatostatin, lanreotide (somatuline), is used in the management of acromegaly and symptoms caused by neuroendocrine tumors, most notably carcinoid syndrome and VIPomas [34]
