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After infectious or sterile stimuli, SLC15A4 in DCs is recruited to phagosomes, SLC15A4deficient DCs infected with Salmonella typhimurium show reduced caspase-1 cleavage and IL-1 production, this correlates with peripheral NLRC4 inflammasome assembly and increased autophagy

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Additional funding was provided by an ERC (the DrEAM) to T.R.W., the NCCR Chemical Biology to S.M., a JSPS Overseas research fellowship to Y.O., Human Frontier Science Program (HFSP) long-term postdoctoral fellowship to R.K

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However, concerns remain regarding the impact of anaphylaxis-related histamine release, which can induce nasal mucosal edema, potentially impairing the absorption of IN epinephrine

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Harris and Attwell, 2012)

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