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The vaccine could maintain its remarkable property and function for at least 12 months of storage at 20 C (Fig

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Upon administration, the Env trimer was released over 2 wk in the skin, correlating with increased germinal centre (GC) B cell responses, a 1,300-fold increase in serum IgG titers, and a 16-fold increase in bone marrow (BM) plasma cells compared with bolus immunization [181]

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