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If subjects do not tolerate the dose increase at the start of week 3, they are kept at the last tolerated dose and maintained for the remainder of the trial
Long-term use of carbamazepine, phenytoin, and rifampin can significantly reduce the steady-state plasma concentrations of these drugs, leading to treatment failure

The entire piece of liver tissue was examined for pathology (approximately 1 square centimeter)

SHP-1 inhibition by 4-hydroxynonenal activates jun N-terminal kinase and glutamate cysteine ligase
