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In this work, by noting that pre-equilibration of ligand-receptor and ternary complex formation occur faster than the receptor internalization and downregulation, we formulate a minimal kinetic model to offer a semi-quantitative yet predictive understanding of the GPCR desensitization and down-regulation
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20 l p -nitroanisole as a substrate for CYP was added to 100 l of the supernatant
[DOI] [PMC free article] [PubMed] [Google Scholar] 211
