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Although growing evidence suggests a role for endosomal PI(4,5)P 2 in cell physiology 4 , our results demonstrate that highly redundant functions of PI(4,5)P 2 phosphatases and SMP proteins keep levels of endosomal PI(4,5)P 2 below a certain threshold to prevent failure of cytokinesis and animal development in vivo

Clear glass vials exposed to standard laboratory lighting lose 1015% potency within 14 days even when refrigerated

PLoS Genet 2 , e108 (2006)
