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Description
Single nucleotide variations (polymorphisms) in the sequence of genes can modify gene expression level and the stability and activity of the synthesized proteins

This systems activity declines with aging, and GHK-Cus restoration of proteasome function likely contributes to its anti-aging effects at the cellular level

Emerging therapeutics for PMS that are discussed in this Review include -lipoic acid, Brutons tyrosine kinase inhibitors, ibudilast and statins

doi: 10.1007/s00228-011-1108-2
