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MC4 (Melanocortin 4) Receptor Agonism Enhances sexual arousal and erections: MC4 activation centrally (in hypothalamus/spinal cord) and peripherally increases sexual motivation and induces penile erection in males and facilitates proceptive sexual behaviors in both sexes 2-4

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Indoles exert many beneficial actions on intestinal and systemic homeostasis 130 .Yet, adverse effects on the gut-brain axis are also evident following absorption from the gut and host processing, where some indole derivatives, have been shown to exert neurodepressive-like affects on behavior, at least in preclinical studies 131

Journal of Korean Medical Science
